王嵬——群体遗传学专家

论文专著：

迄今，已在国内外发表学术论文100余篇。专著1部，参与著书3部，由著名出版社Taylor & Francis及Sciences Press 发行。编写教材3部。多次在美国、英国、澳大利亚、日本、印度及中国举行的大型国际学术会议上作论文报告、重点发言。主持第1，第2届亚洲社区遗传学国际会议。（http://www. communitygeneticsinasia.com）

王嵬博士的英文专著: A Profile of Genetic and Environmental Diseases in China； Science Press（ISBN 978-7-03-023879-5）被选送参加世界规模最大的2009年法兰克福国际书展。

发表论文：

Refereed Articles and Abstracts：

1． Köttgen A, Pattaro C, Böger CA, Fuchsberger C, Olden M, Glazer NL, Parsa A, Gao X, Yang Q, Smith AV, O’Connell JR, Li M, Schmidt H, Tanaka T, Isaacs A, Ketkar S, Hwang SJ, Johnson AD, Dehghan A, Teumer A, Paré G, Atkinson EJ, Zeller T, Lohman K, Cornelis MC, Probst-Hensch NM, Kronenberg F, Tönjes A, Hayward C, Aspelund T, Eiriksdottir G, Launer L, Harris TB, Rampersaud E, Mitchel BD, Arking DE, Boerwinkle E, Struchalin M, Cavalieri M, Singleton A, Giallauria F, Metter J, de Boer I, Haritunians T, Lumley T, Da S, Psaty BM, Zillikens MC, Oostra Ben A , Feitosa M , Province M, de Andrade M, Turner S, Schillert A, Ziegler A, Wild PS, Schnabe RB, Wilde S, Muenzel TF, Leak TS , Illig T, Klopp N, Meisinger C, Wichmann HE, Koenig W, Zgaga L, Zemunik T, Kolcic I, Minelli C, Hu FB , Johansson Å, Igl W, Zaboli G, Wild SH , Wright AF, Campbell H, Ellinghaus D, Schreiber S, Aulchenko YS, Felix JF, Rivadeneira F , Uitterlinden AG, Hofman A, Imboden M, Nitsch D, Brandstätter A, Kollerits B, Kedenko L, Mägi R, Stumvoll M, Kovacs P, Boban M, Campbell S, Endlich K, Völzke H, Kroemer HK, Nauck M, Völker U, Polasek O, Vitart V, Badola S, Parker AlN, Ridke PM, Kardia SLR, Blankenberg S, Liu Y, Curhan GC, Franke A, Rochat T, Paulweber B, Prokopenko I, Wang W, Gudnason V, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, Shlipak MG, Duijn CM , Borecki I, Krämer BK, Rudan I, Gyllensten U, Wilson JF, Witteman JC, Pramstaller P P, Rettig R, Hastie N, Chasman DI, Kao WH, Heid IM, Fox CS(2010) New Loci Associated with Kidney Function and Chronic Kidney Disease: The CKDGen consortium. Nature Genetics 2010: doi:10.1038/ng.568

2． Pučić M, Pinto S, Novokmet M, Knežević A, Gornik O, Polašek O, Vlahoviček K, Wang W, Rudd PM,. Wright AF, Campbell H, Rudan I and Lauc G (2010) Common aberrations from the normal human plasma N-glycan profile. Glycobiology (Oxford Press) Glycobiology, doi:10.1093/glycob/cwq052

3． Yan YX, Liu YQ, Li M, Hu PF, Guo AM, Yang XH, Qiu JJ, Yang SS, Wang W. (2009)Development and evaluation of a questionnaire for measuring suboptimal health status in urban Chinese. Journal of Epidemiology. 2009, doi:10.2188/jea.JE20080086 (corresponding author).

4． Jie Lan, Manshu Song, Chunhui Pan, Guoqing Zhuang, Youxin Wang, Wenzhan Ma, Qiaoyun Chu, Qingxuan Lai, Feng Xu, Yanli Li, Lixin Liu and Wang W (2009) Association between dopaminergic genes (SLC6A3and DRD2) and stuttering among Han Chinese. Journal of Human Genetics (Nature Publishing Group). doi:10.1038/jhg.2009.60 (corresponding author).

5. Wang YX, Chang NB, Zhang T, Liu H, Ma WZ, Chu QY, Lai QX, Liu LX and Wang W。 Overexpression of Human CAP10-Like Protein 46 in T-Acute Lymphoblastic Leukemia and Acute Myelogenous Leukemia. Genetic Testing and Molecular Biomarkers 2010, DOI: 10.1089=gtmb.2009.0145

6． Shumei Zheng and M Song, L Wu, S Yang, X Lu. J Du and Wang W (2009) Public Health Genomics: China’s Aspect. Public Health Genomics. doi:10.1159/000240969 (corresponding author).

7． Guo XH, Zhang PH, Yang SB, Wu W, Sang LL, Luo YX, Li C, Lu XQ, Dai H, Zeng ZC, and Wang W (2009) Ways of Transportation to Work Affect the Levels of Serum Lipids of Beijing Workers. British Journal of Sports Medicine (BMJ group) doi:10.1136/bjsm.2008.049171 (corresponding author).

8. Qizhu Tang, Jun Cai, Difei Shen, Zhouyan Bian, Ling Yan, You-Xin Wang, Jie Lan, Guo-Qing Zhuang, Wen-Zhan Ma, and Wang W（2008）Lysosomal Cysteine Peptidase Cathepsin L Protects against Cardiac Hypertrophy through Blocking AKT/GSK3β signalling. Journal of Molecular Medicine, 2008, 12: 531-543. (corresponding author)

9． Man Li, Wang W, Xinghua Yang, Yuxiang Yan, Qingqing Wu (2008) Evaluation of Indications for Fetal Echocardiography: a Retrospective Review of Clinical Experience. Journal of Ultrasound Medicine. 27: 1291-1298

10． Xiong P, Zeng X, Song MS, Jia SW, Zhong MH, Xiao LL, Lan W, Cai C, Wu, XW, Gong FL, and Wang W. (2008) Lack of association between HLA-A, -B and -DRB1 allele and the development of SARS：a cohort of 95 SARS-recovered individuals in a population of Guangdong, Southern China. International Journal of Immunogenetic. 35:69-74. (corresponding author)

11． R. Xiao, Hai F. Zhao, J. Liang, Huan L. Yu, Jin F. Feng, and Wang W (2007) Developmental neurotoxicity role of cyclophosphamide on post neural tube closure in rodents in vitro and vivo. International Journal of Developmental Neuroscience. 25: 533-537 (corresponding author)

12． Guo XH, Tian XY, Pan YS, Yang XH, Wu SY, Wang W , and Lin, V (2007 ) Managerial Attitudes on the Development of Health Promoting Hospitals in Beijing. Health Promotion International 22: 182-190. (corresponding author)

13． Cai J, Jiang XJ, Lin GS, Shen H, Yi FF, Wang XH, Liu HF, Song J. and Wang W. (2007) Adenoviral Gene Transfer of HCN4 Creates a Genetic Pacemaker in Pigs with Complete Atrioventricular Block. Life Sciences, 80: 1746-1753. (corresponding author)

14． Bittles AH, Black ML. and Wang W. (2007) Physical Anthropology and Ethnicity in Asia: The transition from Anthropometry to Genome-based Studies. Journal of Physiological Anthropology, 26: 77-82.

15． Teng Y, Liu Q, Ma J, Liu F, Han Z, Wang Y, and Wang W. (2006) Cloning, expression and characterization of a novel human CAP10-like gene hCLP46 from CD34+ stem/progenitor cells. Gene 371:7-15. (corresponding author)

16． Xiao R, Qiao JT, Zhao HF, Liang J, Yu HL, Liu J, Guo AM, Wang W. (2006) Sodium selenite induces apoptosis in cultured cortical neurons with special concomitant changes in expression of the apoptosis-related genes. NeuroToxicology. 34 (4) 234-236 . (corresponding author)

17． Yuan J, Yun H, Lan W, Wang W, Sullivan SG, Jia S, and Bittles AH. (2006) A climatological investigation of the SARS-CoV outbreak in Beijing, PR China. American Journal of Infection Control. 34:234-236.. (corresponding author)

18． Liang XY, Nie SF, QU KY, Wei S, Zhu GB, and Wang W. (2006) Evaluation of health-related quality of life of hypertensive patients in rural area, PR China. Journal of Human Hypertension (Nature Publishing Group). 20 (3):227-229. (corresponding author)

19． Sun J, Aoki KZ, Wang W, Guo AM, and Misumi JC. Sodium nitrite-induced cytotoxicity cultured human gastric epithelial cells (2006) Toxicology in Vitro. 20:1133-38.

20． Peng XX, Zhao YL, Liang XY, Wu LJ, Cui SQ, Guo AM, and Wang W. (2006) Assessing the quality of RCT on the effect of b-elemene,one ingredient of a Chinese herb, against malignant tumors. Contemporary Clinical Trials. 27: 70-82. (corresponding author)

21． Black ML, Wang W, and Bittles AH (2006) Genetics and population history in the study of ethnic diversity in PR China. Human Biology, 2006. 78 (3), 277-93.

22． Lu XM, Yang T, Wang X, Ren ZH, Zhang Y, Wen H, and Wang W. (2006) Glutathione-S-transferase M1 polymorphisms on the susceptibility to esophageal cancer among three Chinese minorities: Kazakh, Tajik and Uygur. World Journal of Gestroenterology. 12 (48): 7758-7761. (corresponding author)

23． Wang, W. (2006) Chinese Traditional Chinese Medicine as an effective pharmacological treatment for heroin addiction. Drugs and Alcohol Today, 6:41-48.

24． McElreavey K, Wang W. and Bittles AH. (2005) Report: 1st Asian Genomic and Community Genetics Workshop. Community Genetics. 8:130-132.

25． Jia SW, Wang W, Liu Y, and Wu ZM. (2005) Neuroimaging Studies of Brain Corpus Striatum Changes among Heroin Dependent Patients Treated with Herbal Medicine, U’finer TM Capsule. Addiction Biology. 10:293-297.

26． Li R, Cai Z, Zhong ZG. and Wang W. (2005) Abdominal ultrasound-guided embryo transfer improves clinical pregnancy rates after in –vitro fertilization: experiences from 330 cases of clinical investigations. Journal of Assisted Reproduction and Genetics 22:3-8. (corresponding author)

27． Shao C, Xiong W, and Wang W. (2004) Characterization of rare Dva (Hus) allele at RH loci. Journal of Human Genetics. 49:106-108.

28． Wang W, Wise C, Baric T, Black, ML. and Bittles AH. (2003) The origins and genetic structure of three co-resident Chinese Muslim Populations: the Salar, Bo’an and Dongxiang. Human Genetics. 113: 244-252.

29． Wang W, Jia HL, Wang Q, Cai ZM, Wei LH, Wang DB, and Bittles AH. (2003) STR polymorphisms of ‘forensic loci’ in northern Han Chinese population. Journal of Human Genetics. 48:337-341

30． Wise C, Paris M, Morar B, Wang W, Kalaydjieva L. and Bittles AH. (2003) Single nucleotide polymorphism analysis using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry: Optimization and applications in human genetics. Rapid Communications in Mass Spectrometry. 17:1195-1202.

31． Teng Y, Wang W, Tian H, Wang H, Hu X, Chen Y. and Bittles AH. (2003) Autosomal dominant retinitis pigmentosa in a 5-generation pedigree in pr china. Eye. (Nature Publishing Group) 17, 1036-1039. (corresponding author)

32． Huang YF, Wang W, Han JY, Zhang ST, Liu CJ, Hu QG., Xiong P, Wu XW, Hamvas R, Wood N, Gong, FL. and Bittles AH. (2003): Association of mannose-binding lectin (MBL) LX haplotype with Chinese SLE patients. European Journal of Immunogenetics. 30: 121-124.

33． Wang W, Qian C. and Bittles AH. (2002) Consanguineous marriage in PR China: a study in rural Man (Manchu) communities. Annals of Human Biology. 29, 685-690.

34． Black M, Wang W. and Bittles AH. (2001) A genome-based study of the Muslim Hui community and the Han population of Liaoning Province, PR China. Human Biology. 73, 801-813.

35． Kulski JK, Martinez P, Shiina H, Jacobsen N, Wang W, Naruse T, Inoko H, and Dawkins RL. (2001) The detection of a strong but imperfect association between HLA-A2 and the newly identified domorphic Alu insertion near HLA-G. Journal of Molecular Evolution, 53,114-123.

36． Wang W and Bittles AH. (2001) Imperfect units of an extended microsatellite structure involving single nucleotide changes. Electrophoresis. 22, 1095-1097.

37． Zhivotovsky LA, Suhaib A, Wang W and Bittles AH. (2001) Deep genetic differentiation among co-resident endogamous communities and its forensic DNA implications. Forensic Science International. 119, 269-272.

38． Ahmed S, Wang W, Sullivan S and Bittles AH. (2000) The influence of long-term inbreeding on human genome structure in three endogamous Pakistan communities. DNA Polymorphism 8, 145-149.

39． Bittles AH, Kumm J, Wang W, Di Grandi S, Savithri HS, and Appaji Rao N, (2000) Calculating a genomic estimate of consanguinity. Journal of Medical Genetics. 37 Supp., 70.

40． Baric T, Wang W. and Bittles AH. (2000) Genetic diversity among the Salar, Bo’an, and Dongxiang Muslim populations in the Peoples Republic of China. Journal of Medical Genetics. 37 Supp., 69.22.

41． Baric T, Worsley P, Wang W, Kalaydjieva L, and Bittles AH. (2000) MALDI-TOF mass spectrometry and single nucleotide polymorphism analysis in human populations. Journal of Medical Genetics. 37 Supp., 71.

42． Wang W. and Bittles, A.H. (2000) Allelic homoplasy of STR due to variable allelic flanking sequences: SNPs in STR. American Journal of Human Genetics. 67 Supp., 220

43． Savithri HS, Venkatesha Murthy HS, Baskaran,G, Appaji Rao N, Kool D, Edkins E, Wang W. and Bittles AH. (2000) Predictive testing for familial adenomatous polyposis in a rural South Indian community. Clinical Genetics 8, 57-60.

44． Savithri HS, Venkatesha Murthy HS, Baskaran G, Appaji Rao N. Wang W. and Bittles, A.H. (2000) Mutation detection and predictive testing for familial adenomatous polyposis in a rural South Indian community. DNA Polymorphism 8, 63-65.

45． Wang W, Black M, Qian C, Jia HL, and Bittles A. H. (2000) Autosomal and Y-chromosome allele profiles in co-resident Han and Hui communities in northeast China. DNA Polymorphism 8, 167-171.

46． Wang W, Sullivan S, Ahmed S, Chandler D. Zhivotovsky LA, and Bittles AH. (2000) A genome-based study of consanguinity in three endogamous Pakistan communities. Annals of Human Genetics 64, 41-49.

47． Ahmed S, Wang W, Sullivan S, Chandler D. and Bittles A.H. (1999) Microsatellite analysis of autosomal and Y-chromosome variation in three consanguineous communities in Pakistan. Annals of Human Biology 26, 394-395.

48． Bittles AH, Wang W, Nan L, Shuzhuo L, Feldman MW. (1999) Effects of the 1981 marriage Act of China on the prevalence and patterns of marital union. Annals of Human Biology 26, 397-398.

49． Bittles AH, Wang W, Di Grandi S, Cahill J, Savithri HS, Venkatesha Murthy HS, Baskaran G. and Appaji Rao, N. (1999) A DNA-based analysis of long-term human inbreeding. Journal of Medical Genetics 36 supp., 31.

50． Savithri HS, Venkatesha Murthy, HS, Appaji Rao N, Cahill J, Wang W. and Bittles, A.H. (1998) Genomic analysis of long-term consanguinity in a rural south Indian community. Annals of Human Biology 25, 290-291.

51． Wang W, Okazaki, Kishida T, Fukuda M. and Tamaki Y. (1997) Subtyping of D20S85 STR alleles by single-strand conformation polymorphism (SSCP) analysis. Forensic Science International 86, 187-192.

52． Kishida T, Wang W, Fukuda M. and Tamaki Y. (1997) Duplex PCR of the Y-27H39 and HPRT loci with reference to Japanese population data on the HPRT locus. Japanese Journal of Legal Medicine 51, 67-69.

53． Okazaki K, Kishida T, Wang W , Fukuda M, Nakamura M. and Tamaki,Y (1996) STR typing of buccal swabs for paternity testing with reference to Japanese population data on D20S85, D14S118, and D14S543 loci. Japanese Journal of Legal Medicine 50, 404-411.

54． Fukuda M, Kishida T, Wang W and Tamaki Y. (1996) STR typing in a deficiency case of disputed paternity. Japanese Journal of Legal Medicine 50, 422-426.

55． Fukuda M, Tamaki Y, Kuroki K, Kishida T. and Wang W. (1996) Production of monoclonal anti-thymine-dimer antibody and its use for detection of STR alleles. Japanese Journal of Legal Medicine 50, 343-348.

56． Kishida, T, Fukuda M, Wang W. and Tamaki Y. (1996) Determination of sibship by microsatellite typing in a deficiency case of disputed maternity. Japanese Journal of Legal Medicine 50, 361-365.

57． Kishida T, Wang W, Fukuda, M. and Tamaki, Y. (1996) Two deficiency cases of disputed paternity: sibling or half-sibling? Japanese Journal of Legal Medicine 50, 78-81.

58． Kishida T, Fukuda M, Okazaki K, Wang W. and Tamaki Y. (1996) DNA typing by triplex affinity capture (TAC) PCR. Japanese Journal of Legal Medicine 50, 255-257.

59． Wang W, Fukuda M, Kishida T. and Tamaki Y. (1996) Quintuplex PCR amplification of microsatellite. Japanese Journal of Legal Medicine 50, 231-236.

60． Wang W, Kishida T, Fukuda M and Tamaki Y. (1996) The Y-27H39 polymorphism in a Japanese population. International Journal of Legal Medicine 109, 157-158.

61． Kishida T, Tamaki Y., Kuroki K., Fukuda M. and Wang W. (1995) PCR amplification of D2S44 (YNH24) alleles. Japanese Journal of Legal Medicine 49, 299-301.

62． Tamaki Y, Fukuda M, Kishida T. and Wang W. (1995) Preparation of multi-locus cocktail by liquid-phase reassociation. Japanese Journal of Legal Medicine 49, 251-254.

63． Wang W, Liu H and Jia JT. (1991) Modified method for showing Gc subtypes and the discovery of two new variants of Gc subtypes from Chinese. Journal of China Medical University 20 Supp., 29-32.

64． Qi S W, Jia, JT and Wang W. (1991) Ultrasensitive Silver staining for the detection of protein genetic markers and its application to forensic practice (In Chinese). Chinese Journal of Forensic Medicine 6, 123-125.

65． Qi SW, Jia JT and Wang W. (1990) Transferrin (Tf) phenotyping in Chinese Han and its detection in bloodstains (In Chinese). Chinese Journal of Forensic Medicine 5, 97-99. In Chinese.

66． Qi S W, Jia JT and Wang W. (1989) Genetic Polymorphisms of: a -1-antitrypsin and transferrin, and their application to Forensics (In Chinese). Chinese Journal of Forensic Medicine 4, 117-120.

67． Wang W. and Jia JT. (1987) Phenotyping of phosphoglucomutase (PGM1) subtypes in Chinese, with special reference to new variant PGM1 China. Medicine Science and Law. 27, 280-283.

Book chapters：

Bittles, A.H., Savithri, H.S., Venkatesha Murthy, H.S., Wang, W., Cahill, J., Bhaskaran, G. and Appaji Rao, N. (2001) Consanguineous marriage, a familiar story full of surprises. In Health and Ethnicity, eds. H. Macbeth and P. Shetty, Taylor and Francis, London. pp 68-78

Black, M.L., Wang, W. and Bittles, A.H. (2007) Unity and diversity: genetic studies on the population of China. In Recent Advances in Molecular Biology and Evolution. Editors: Cristina Santos and Manuela Lima, Kerala, India. pp 348-371

Book：

Wang W. (2009) A Profile of Genetic and Environmental Disease in China. Science Press, Beijing ISBN 978-7-03-023879-5