科学研究：

研究方向：

主要从事间充质干细胞体内自我更新、分化以及衰老的调控机制；骨骼发育、骨代谢以及骨质疏松症的发病机理；DNA损伤应激发应、衰老以及肿瘤发生的研究。

承担科研项目情况：

1． 体内间充质干细胞自我更新、分化及其调控相关组织干细胞的机制研究，首席科学家。

2． Atm 介导的Smad1 磷酸化在DNA损伤应激反应及肿瘤发生中的作用，负责人。

3． 通过协调经典的Smad通路和非经典的MAPK通路调节BMP的功能以及成骨细胞分化，负责人。

科研成果：

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论文专著：

在Nature Genetics、Genes and Development、PNAS、Journal Cell Biology， Human Molecular Genetics， Cell等杂志发表40余篇学术文章。

出版专著：

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发表英文论文：

1.Gang Ma, Lili Li, Yuanyu Hu, Bijin Au, Lin He and Baojie Li* (2012). P53 represses Smad1 expression via p21-E2F pathway to control mesenchymal stem cell differentiation. J Mol Cell Biol, 4(2): 118-120.

2.Jenny Chau, Yuanyu Hu, Jianhe Wang, Zhi Liu, Bi Jin Au, Yuji Mishina, Ye-Guang Chen, Christine Biondi, Elizabeth Robertson, Yue-Zheng Du, Dong Xie, Xueying Wang, Qiang Yu, and Baojie Li* (2012). Integration of BMP signaling and Atm-p53 pathway at Smad1 in DNA damage response and oncogenesis. Nature Communications, In press.

3.Keng Po Lai, Wai Fook Leong, Jenny Fung Ling Chau, Deyong Jia, Li Zeng, Huijuan Liu, Aijun Hao, Lin He, Hongbing Zhang, David Meek, Chakradhar Velagapudi, Samy L. Habib, and Baojie Li* (2010). S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response. EMBO J., 29(17):2994-3006.

4. Leong W, Zhou T, Li B*. Protein palmitoylation regulates osteoblast differentiation through BMP-induced osterix expression. PLoS One. 2009; 4(1): e4135.

5. Wang X, Goh CH, Li B*. p38 MAPK regulate osteoblast differentiation through osterix. Endocrinology. 2007; 148(4):1629-1637.

6. Rasheed N, Wang X, Niu QT, Yeh J, Li B*. Atm deficient mice: an osteoporosis model with defective osteoblast differentiation and increased osteoblastogenesis. Human Molecular Genetics. 2006; 15(12): 1938-1948.

7. Wang X, Kua HY, Hu Y, Guo K, Zeng Q, Wu Q, Ng HH, Karsenty G, de Crombrugghe B, Yeh J, Li B*. p53 represses the expression of transcription factor osterix and functions as a negative regulator of osteoblastogenesis and bone formation. J. Cell Biol. 2006; 172:115-125.

8. Hu Y，Wang X，Zeng L，Cai D，Sabapathy K，Goff SP，Firpo EJ and Li B* (2005). ERK phosphorylates p66shcA on Ser36 and subsequently regulates p27kip1 expression via the Akt-FOXO3a pathway: implication of p27kip1 in cell response to oxidative stress. Mol. Biol. Cell. 16:3705-3718.

9. Li B*, Wang X, Rasheed N, Hu Y, Boast S, Ishii T, Nakayama K, Nakayama KI, Goff SP. Distinct roles for c-Abl and Atm in Prx I induction by modulating expression of protein kinase C. Genes and Development. 2004; 18:1824-1837.

10. Hu Y, Chan E, Wang X, and Li B* (2003) Activation of p38MAPK is required for osteoblast differentiation. Endocrinology 144(5):2068-2074.

11. Li B, Boast B, de los Santos K, Schieren I, Quiroz M, Teitelbaum SL, Tondravi MM, and Goff SP (2000). c-Abl knockout mice are osteoporotic and show defects in osteoblast maturation. Nature Genetics 24(3): 304-308.

发表中文论文：

1 博来霉素A_5和异博定联合用药对小鼠免疫功能的影响 李保界; 张鸿卿; 薛绍白; 高平; 王瑞海; 李嗣英 北京师范大学生物系; 中国医学科学院医药生物学技术研究所 【期刊】北京师范大学学报(自然科学版) 1991-03-02

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荣誉奖励：

1． 2009年入选上海“浦江人才”计划。

2． 2001年获美国HHMI和Cancer Research Institute博士后基金。

3． 获美国骨矿研究协会“事业提升奖”(ASBMR: Career Enhancement Award， USA)。

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